Renin inhibitors block the activity of renin and cause vasodilatation. Renin is an enzyme that converts angiotensinogen to angiotensin I, which is then converted to angiotensin II by angiotensin converting enzyme. Angiotensin II is a potent vasoconstrictor that causes the blood pressure to rise.
Renin inhibitors are used to treat hypertension.
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Source:drugs.com
Aliskiren
Aliskiren is used alone or in combination with some medications to treat high blood pressure. Aliskiren is in a class of medications called direct renin inhibitors. It works by decreasing certain natural chemicals that tighten the blood vessels, so blood vessels relax and the heart can pump blood more efficiently.
